This evidence-based guide provides everything you need—whether you’re completely new to supplements, an experienced user, or a seasoned healthcare professional—to significantly enhance safety, optimize your MDMA experience, and support rapid, effective recovery.
Below is a clear, step-by-step navigation to ensure everyone can quickly find exactly what they need, without feeling overwhelmed.
| Your Goal | Ideal for | Where to Start | Time Needed |
|---|---|---|---|
| 🚀 Fast Essentials | Busy individuals, first-timers, minimalists | Minimal Protocol (Table 2) | ~5 minutes |
| ⚖️ Balanced Understanding | Regular MDMA users, wellness enthusiasts | Core Protocol Sections (Before, During, After) | ~20-30 minutes |
| 🔍 Deep Scientific Dive | Scientists, clinicians, dedicated enthusiasts | Comprehensive Document & Appendix Tables | 1 hour or more |
Here’s your simplified supplement schedule for safer MDMA use:
| Phase | Supplement | Dosage & Timing | Reason |
|---|---|---|---|
| Before MDMA(3-6 hrs) | Alpha Lipoic Acid | ||
| Acetyl-L-Carnitine | |||
| Vitamin C | |||
| Magnesium Glycinate | 300-600mg (ALA) | ||
| 500-1000mg (ALCAR) | |||
| 1000mg (Vit C) | |||
| 200mg Mg (1 hr prior) | Protect brain cells, prevent damage, reduce tension | ||
| During MDMA(0-6 hrs) | Alpha Lipoic Acid | ||
| Electrolytes | |||
| Magnesium Glycinate | 300mg every 2 hrs | ||
| Regular small sips (max 500ml/hr) | |||
| 100-200mg as needed | Maintain protection, hydration, prevent jaw clenching | ||
| After MDMA(same night & next days) | Melatonin | ||
| N-Acetylcysteine (NAC) | |||
| 5-HTP + EGCG (24+ hrs after) | 5-10mg before sleep | ||
| 600mg twice daily | |||
| 100mg 5-HTP + 400mg EGCG nightly (after 24 hrs) | Support recovery, restore serotonin, promote sleep |
Dive deeper into the sections below to understand why each supplement is recommended, its benefits, and exactly how and when to use it: